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COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells
Solomon S Shaftel1, John A Olschowka, Sean D Hurley
1Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.
Abstract:
We have detected an expressed mRNA encoding a splice variant of COX-1 in the mouse central nervous system. This isoform, referred to as COX-3, is identical in sequence to COX-1 except for the in-frame retention of intron 1. Like its counterpart COX-1, COX-3 does not generally appear to be induced by acute inflammatory stimulation.
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