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Published on: December 11, 2017
Pressure recovery in pediatric aortic valve stenosis
R E Villavicencio1, T J Forbes, R L Thomas
1Department of Pediatrics, Division of Cardiology, Wayne State University School of Medicine/Detroit Medical Center and Children's Hospital of Michigan, 3901 Beaubien Avenue, Detroit, MI 48201, USA.
Insights
Pressure recovery significantly impacts aortic stenosis gradient measurements in children. Correcting Doppler echocardiography gradients using the pressure recovery equation improves accuracy compared to peak or mean gradients.
Area of Science:
- Pediatric Cardiology
- Echocardiography
- Hemodynamics
Background:
- Doppler echocardiography often overestimates aortic valve stenosis gradients compared to catheterization.
- Pressure recovery is a known factor contributing to this overestimation.
- The clinical utility of pressure recovery correction in pediatric aortic stenosis is not well-established.
Purpose of the Study:
- To evaluate pressure recovery in pediatric patients with aortic stenosis.
- To assess if Doppler echocardiography can predict discrepancies between catheter and Doppler gradients using pressure recovery.
- To determine the clinical relevance of pressure recovery corrected Doppler gradients in children.
Main Methods:
- Simultaneous catheter and Doppler gradients were measured in 14 pediatric patients with aortic valve stenosis.
- Data included pre- and post-balloon valvuloplasty measurements.
- Pressure recovery was calculated using a validated equation, and Doppler gradients were compared to catheter gradients.
Main Results:
- Peak Doppler gradients consistently overestimated catheter gradients.
- Pressure recovery corrected Doppler gradients showed better agreement with catheter gradients than uncorrected peak or mean Doppler gradients.
- The correlation coefficient between catheter gradients and Doppler-derived gradients (peak, mean, and corrected) was high (r = 0.92).
Conclusions:
- Pressure recovery is a significant factor in pediatric aortic valve stenosis.
- The pressure recovery equation can predict the difference between catheter and Doppler gradients.
- Correcting Doppler gradients for pressure recovery enhances their accuracy in pediatric patients.
Abstract:
This study was designed to evaluate the phenomenon of pressure recovery in pediatric patients with aortic stenosis and also to evaluate how observed differences between catheter and Doppler gradients can be predicted by Doppler echocardiography. Doppler measurements of aortic valve stenosis gradients are known to overestimate observed gradients in the catheterization laboratory. Pressure recovery has been shown to be a contributing factor to this discrepancy. However, the clinical relevance of correcting Doppler gradients using the pressure recovery equation has not been evaluated in the pediatric population. Simultaneously obtained catheter and Doppler gradients were studied in 14 patients (range, 0.03-18 years; mean, 4.1 years) with aortic valve stenosis. A total of 23 data points were measured because 9 patients underwent balloon valvuloplasty and had both a pre- and a post-balloon valvuloplasty data point in the study. The catheter gradients were then compared to peak, mean, and pressure recovery corrected Doppler gradients. Pressure recovery was calculated using a previously validated equation. As expected, measured echocardiographic continuous-wave peak Doppler gradients overestimated the observed catheter gradients (range, 16-93 mmHg; mean, 43 mmHg). The continuous-wave peak Doppler gradients, mean, and pressure recovery adjusted gradients were equally as good in correlating the observed catheter gradients to those obtained by Doppler echocardiography (r = 0.92). However, pressure recovery corrected Doppler gradients were in better agreement with catheter gradients than echocardiographic mean or peak Doppler gradients (95% limit of agreement: -9 to 19 mmHg for pressure recovery corrected gradients, -30 to 11 mmHg for mean Doppler gradients, and 2-83 mmHg for peak Doppler gradients). Measured continuous-wave peak Doppler gradients consistently overestimated catheter gradients. The noted differences may be predicted using the pressure recovery equation. Pressure recovery is a significant factor in children with aortic valve stenosis.
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