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Published on: September 25, 2019
Prevention and treatment of hepatitis B recurrence after liver transplantation
Jian-Ping Zhu1, Tong-Lin Zhang, Lei Li
1Department of Surgery, Third Hospital of Peking University, Beijing 100083, China. zhujianpingwz@yahoo.com.cn
Objective:
To study the efficacy of liver transplantation on end-stage hepatitis B related liver diseases, and the prevention and treatment strategies of hepatitis B recurrence after the transplantation.
Methods:
The efficacy of combined treatment of lamivudine and hepatitis B immune globulin (HBIG) therapy on 24 patients who had received liver transplantation was retrospectively studied.
Results:
All the 24 patients with end-stage hepatitis B-related liver diseases treated with lamivudine alone or combined therapy of lamivudine and HBIG showed normal liver function and 21 of them lost hepatitis B virus (HBV) markers. However, the remaining 3 patients became HBsAg positive again soon after liver transplantation.
Conclusions:
Liver transplantation is effective for patients with end-stage hepatitis B-related liver diseases. Combined treatment of lamivudine and HBIG may prevent the recurrence of hepatitis B after the operation.
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