Related Experiment Video
Updated: Aug 30, 2026

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Platelet activation and the protective effect of aprotinin in hepatolithiasis patients
Wen-Ming Feng1, Ying Bao, Mao-Yun Fei
1Department of Hepatobiliary Surgery, First Hospital of Huzhou, Huzhou 313000, China. d_fwm@hotmail.com
Objective:
To explore platelet activation and the protective effect of aprotinin in patients with hepatolithiasis.
Methods:
The count of platelets and levels of CD62P and CD63 were measured by flow cytometry in 38 patients with hepatolithiasis. Several measurements were carried out after treatment with aprotinin.
Results:
The levels of CD62P, CD63 in patients with hepatolithiasis were higher than those in patients with cholecystolithiasis (P<0.05), but the count of platelets was lower (P<0.05). After operation, the levels of CD62P, CD63 were significantly increased in patients with hepatolithiasis, but the count of platelets was lower (P<0.05). Postoperative levels of CD62P, CD63 were significantly lower in patients treated with aprotinin than in normal controls (P<0.05); but there was no significant change in the count of platelets in the two groups.
Conclusion:
Platelet activation occurs in patients with hepatolithiasis, and may be inhibited by aprotinin.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Clot Retraction and Fibrinolysis
Venous Thrombosis III: Interprofessional Care
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
