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Related Experiment Videos

Allocortical neurofibrillary changes in progressive supranuclear palsy.

H Braak1, K Jellinger, E Braak

  • 1Zentrum der Morphologie, J.W. Goethe-Universität, Frankfurt/Main, Federal Republic of Germany.

Acta Neuropathologica
|January 1, 1992
PubMed
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Progressive supranuclear palsy (PSP) involves neurofibrillary tangles and neuropil threads, primarily in the allocortex. Severe entorhinal cortex destruction correlates with dementia in PSP patients, impacting cognitive function.

Area of Science:

  • Neuroscience
  • Neuropathology
  • Neurodegenerative Diseases

Background:

  • Progressive supranuclear palsy (PSP) is a neurodegenerative disease.
  • Understanding the neuropathological basis of cognitive impairment in PSP is crucial.

Purpose of the Study:

  • To investigate the pattern and extent of cerebral cortical lesions in progressive supranuclear palsy.
  • To correlate neuropathological findings with cognitive status (dementia vs. unimpaired).

Main Methods:

  • Silver staining techniques were used to examine neurofibrillary tangles, neuropil threads, and A4-amyloid deposits in the cerebral cortex of six PSP cases.
  • Cases were categorized based on cognitive status: three mentally unimpaired and three with moderate dementia.

Main Results:

Related Experiment Videos

  • A4-amyloid deposits were minimal or absent in all cases.
  • Neurofibrillary tangles and neuropil threads were prevalent, mainly confined to the allocortex.
  • A distinct pattern of entorhinal cortex damage was observed: mild changes in unimpaired individuals and severe superficial cellular layer destruction in demented patients.

Conclusions:

  • The observed allocortical destruction, particularly in the entorhinal cortex, resembles changes seen in early Alzheimer's disease and dementia with Lewy bodies.
  • Destruction of the entorhinal cortex may disconnect the hippocampus from the isocortex, contributing to cognitive impairment and personality changes in PSP.