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Elevated blood pressure in HIV-infected individuals receiving highly active antiretroviral therapy

Dominic C Chow1, Scott A Souza, Randi Chen

  • 1Hawaii AIDS Clinical Research Program, Leahi Hospital, 3675 Kilauea Avenue, 5th Floor, Honolulu, Hawaii 98616, USA. dominicc@hawaii.edu

HIV Clinical Trials
|November 25, 2003
PubMed

Insights

Highly active antiretroviral therapy (HAART) containing protease inhibitors or nonnucleoside reverse transcriptase inhibitors can increase blood pressure in HIV patients. Nucleoside reverse transcriptase inhibitor-only regimens did not show significant blood pressure changes.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antiretroviral therapy is crucial for managing HIV infection.
  • The impact of different antiretroviral regimens on cardiovascular health, specifically blood pressure, requires further investigation.

Purpose of the Study:

  • To examine the effects of various antiretroviral regimens on blood pressure (BP) in HIV-infected individuals.
  • To compare BP changes among patients receiving different highly active antiretroviral therapy (HAART) combinations and untreated controls.

Main Methods:

  • A retrospective study analyzed systolic and diastolic BP (SBP and DBP) data from HIV-infected participants between 1995 and 2001.
  • Linear regression estimated annual BP changes, comparing HAART groups (protease inhibitor-based, NNRTI-based, NRTI-only) to untreated controls.

Main Results:

  • Initiating HAART was associated with increased SBP (4.71 mmHg/year) and DBP (2.26 mmHg/year).
  • PI-containing HAART showed increases of 4.75 mmHg/year (SBP) and 1.96 mmHg/year (DBP).
  • NNRTI-containing HAART showed increases of 3.21 mmHg/year (SBP) and 2.62 mmHg/year (DBP); NRTI-only regimens had no significant BP changes.

Conclusions:

  • HAART regimens incorporating protease inhibitors or nonnucleoside reverse transcriptase inhibitors are linked to elevated SBP and DBP in HIV-infected individuals.
  • The findings highlight the importance of monitoring blood pressure in patients undergoing specific antiretroviral treatments.
Abstract

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