Related Experiment Videos
Procoagulant changes induced by oral contraceptives are balanced by an increased fibrinolytic tendency
I J Mackie1, S Campbell, M Gallimore
1Haematology Department, University College and Middlesex School of Medicine, London, U.K.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
Oral contraceptives caused increased fibrinogen, FVII, FX, and fibrinolysis. The latter was associated with elevated FXII and PKK, while C1-INH was decreased, ATIII and alpha 2M were unchanged; it could not be accounted for by changes in t-PA, u-PA, PAI, plasminogen, alpha 2-AP, proteins C or S. HCII and alpha 1-PI were increased and may regulate the availability of thrombin and FXIa. The increased FXII/PKK dependent fibrinolytic potential and HCII may offset any increase in thrombin generation, while alpha 1-PI limits intrinsic coagulation.