Related Experiment Video
Updated: Aug 9, 2026

Expansion and Adipogenesis Induction of Adipocyte Progenitors from Perivascular Adipose Tissue Isolated by Magnetic Activated Cell Sorting
Published on: June 30, 2017
[Effects of catecholamines on human preadipocyte proliferation and differentiation]
Xiao-hai Zhu1, Qing-lian He, Zi-hao Lin
1Plastic Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Objective:
To study the effects of catecholamines on human preadipocyte proliferation and differentiation.
Methods:
Catecholamines (epinephrine, isoprenaline and noradrenaline) were added to the culture media of human preadipocytes. The proliferation of cells, the expression of GPDH and lipid droplet accumulation in cytoplasm were observed and recorded. The functions of alpha and beta receptors were examined with adding alpha and beta receptor blockers.
Results:
Epinephrine and isoprenaline stimulated human preadipocyte proliferation and inhibited GPDH up-regulation during differentiation. The three types of catecholamines inhibited lipid accumulation in cell differentiation. The beta-adrenoceptors played a key role during the process.
Conclusion:
Human preadipocytes responded to catecholamine characteristically. The result would be applicable in the study of drugs for obesity.
More Related Videos
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
Two...
cAMP-dependent Protein Kinase Pathways

