Renal alteration and development of hypertension in diabetic rats

There is a close association between diabetes and hypertension. Many studies have demonstrated an increased incidence of hypertension in the presence of diabetic nephropathy. The aim of the present work was to study the kallikrein-kinin system during the diabetic states with hypertension. In this study neonatal rats were injected with streptozotocin at two days of age. Plasma glucose, proteinuria, urinary kallikrein, blood pressure, creatinine clearance, diuresis and body weight were measured.

control rats vs diabetic rats. Plasma glucose (mg/dl): 0 minutes 80.2 +/- 2.5 vs 105.5 +/- 4.5; 60 minutes 120.4 +/- 2.3 vs 220.0 +/- 4.6; 120 minutes 105.0 +/- 1.5 vs 140.0 +/- 3.6; p < 0.05. Proteinuria at 8 months of age (mg/24 hs): 12.5 +/- 1.6 vs 20.6 +/- 2.4; p < 0.05. Urinary kallikrein at 8 months of age (umol/min/24 hs)/(ml/min) x 10(3): 46.9 +/- 3.0 vs 28.5 +/- 2.5; p 0.005. Blood pressure at 8 months of age (mm Hg): 110.0 +/- 2.0 vs 132.0 +/- 4.0; p < 0.001. Creatinine clearance at 10 months of age (ml/min): 0.46 +/- 0.03 vs 0.70 +/- 0.14; p < 0.05. Diuresis at 8 months of age (ml/24 hs): 1.55 +/- 0.65 vs 10.30 +/- 1.44, p < 0.001. The early modifications of kallikrein-kinin system in the diabetes states may contribute to development hypertension with modifications in the hemodynamics renal function.