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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Cefepime (maxipime) in the treatment of severe urinary tract infection]

I I Derevianko1

  • 1Research Insitute of Urology, Ministry of Public Health of the Russian Federation, Moscow.

Antibiotiki I Khimioterapiia = Antibiotics and Chemoterapy [Sic]
|November 25, 2003
PubMed

Insights

Cefepime demonstrated high clinical and bacteriological efficacy in treating complicated urinary tract infections (cUTIs). This study compared its effectiveness against other antibiotics, finding it a successful monotherapy option for cUTI patients.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Complicated urinary tract infections (cUTIs) pose a significant clinical challenge.
  • Antimicrobial resistance necessitates evaluation of effective treatment options.

Purpose of the Study:

  • To compare the susceptibility of microflora isolates from cUTI patients to cefepime and other antibiotics.
  • To evaluate the clinical and bacteriological efficacy of cefepime monotherapy in treating cUTIs.

Main Methods:

  • Microflora isolates from cUTI patients were identified.
  • Susceptibility testing was performed for cefepime, other cephalosporins, amikacin, ciprofloxacin, and ofloxacin.
  • Patients received cefepime monotherapy (1-2g daily) for 7-14 days.

Main Results:

  • Cefepime exhibited high clinical efficacy at 93.2%.
  • Bacteriological efficacy of cefepime was 85.4%.
  • Isolates were identified within diagnostic titers ranging from 5 x 10(4) to 5 x 10(8).

Conclusions:

  • Cefepime is an effective etiotropic monotherapy for complicated urinary tract infections.
  • The study supports the use of cefepime in managing cUTIs based on its high efficacy rates.

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