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Updated: Aug 14, 2026

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A Delayed Inoculation Model of Chronic Pseudomonas aeruginosa Wound Infection
Published on: February 20, 2020
Hageman factor dependent activation and its relationship to lethal Pseudomonas aeruginosa burn wound infections
1Department of Surgery, University of Cincinnati College of Medicine, Ohio.
Abstract:
Trauma causes increases in total protease load in the circulation of the traumatized host animal or patient. This increase is due, in part, to Hageman Factor activation followed by down-line cascade system activation. Concomitant with the activation of these systems is a reduced host capacity to resist infection. Infection superimposed on a traumatized host increases the total host protease load even more by additional activation of Hageman Factor and cascade systems.

