Application of genomics and proteomics in Type 1 diabetes pathogenesis research
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Thomas Sparre1, Regine Bergholdt, Jørn Nerup
1Steno Diabetes Center, Gentofte, Denmark. tspa@steno.dk
Abstract:
Type 1 diabetes is a polygenic, multifactorial autoimmune disease characterized by selective and irreversible destruction of the insulin-producing beta-cells in the pancreatic islets of Langerhans. An exogenous supply of insulin is required to sustain life after the onset of Type 1 diabetes. Despite decades of intensive research into its pathogenesis, no single gene or protein has been found to be responsible for Type 1 diabetes. This review will describe the use of large-scale genomics and proteomics in studying the pathogenesis of Type 1 diabetes, and will discuss future directions of research in the field.
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