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Updated: Aug 30, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Follow-up for high-grade dysplasia in Barrett's esophagus
Mohammed A Kara1, Jacques J G H M Bergman, Guido N J Tytgat
1Department of Gastroenterology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Abstract:
This article will focus on the value of endoscopic follow-up for patients with high-grade dysplasia (HGD). Because the diagnosis of HGD in Barrett's esophagus is not a simple straightforward task, the article first will discuss the controversies regarding the histological diagnosis, followed by a discussion of the importance of endoscopic imaging for making the clinical diagnosis of HGD, and a systematic review of the literature relating to the presence of synchronous cancers in patients with HGD and the occurrence of cancer during endoscopic follow-up in these patients (metachronous cancers). Furthermore, the article will also discuss endoscopic techniques currently available for surveillance of these patients and make recommendations regarding surveillance intervals and the optimal biopsy protocol.
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