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Related Experiment Videos

Pasteurella multocida endocarditis.

S M Hombal1, H P Dincsoy

  • 1Department of Laboratories, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.

American Journal of Clinical Pathology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Pasteurella multocida causes severe infections, including rare endocarditis, particularly in immunocompromised individuals. Early diagnosis and treatment are crucial for this potentially life-threatening zoonotic disease.

Area of Science:

  • Veterinary Medicine
  • Infectious Diseases
  • Human Pathology

Background:

  • Human infection with Pasteurella multocida is a common consequence of animal bites.
  • Life-threatening Pasteurella multocida infections can occur in immunocompromised patients or those with underlying health conditions.
  • Infective endocarditis caused by P. multocida is exceptionally rare, with limited reported clinical cases.

Observation:

  • An autopsy case of a 61-year-old male with polycystic kidney disease revealed P. multocida bacteremia and acute infective endocarditis.
  • The patient presented with multiple bacterial clumps on the bicuspid aortic valve.
  • The P. multocida infection was likely acquired through direct contact with a pet dog's saliva on leg ulcers, indicating an animal-to-human transmission route.

Findings:

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  • The causative agent was identified as gram-negative bacteria, Pasteurella multocida.
  • The autopsy confirmed P. multocida bacteremia and acute infective endocarditis involving the aortic valve.
  • The case highlights a potential zoonotic transmission pathway from a pet dog to a human with underlying kidney disease.

Implications:

  • Pasteurella multocida, a common animal commensal, may cause more human infections than currently recognized.
  • A high index of suspicion is necessary for early diagnosis of P. multocida infections, especially in immunocompromised individuals.
  • Prompt diagnosis and treatment are essential as P. multocida infections can be life-threatening but are treatable.