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Related Experiment Videos

Osteolysis after silicone arthroplasty.

S L Harboldt1, G J Gumley, K Balogh

  • 1Department of Pathology, New England Deaconess Hospital, Boston, Massachusetts 02215.

American Journal of Clinical Pathology
|December 1, 1992
PubMed
Summary

Silicone from a lunate prosthesis caused giant cell bone lesions mimicking tumors in a patient with avascular necrosis. These lesions, characterized by reactive synovitis and histiocytes, highlight a rare complication of orthopedic implants.

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Area of Science:

  • Orthopedic Surgery
  • Pathology
  • Biomaterials Science

Background:

  • Avascular necrosis of the lunate can necessitate prosthetic replacement.
  • Silicone implants are used in orthopedic procedures.
  • Giant cell lesions of bone can present diagnostic challenges.

Observation:

  • A patient with a silicone lunate prosthesis developed painful lytic bone lesions.
  • Reoperation revealed reactive synovitis extending into the bone lesions.
  • Histology showed granulation tissue with multinucleated giant cells containing refractile silicone particles.

Findings:

  • The bone lesions were characterized by abundant reactive synovitis.
  • Histologic examination confirmed the presence of silicone particles within giant cells.
  • The presentation mimicked a neoplastic process both radiographically and microscopically.

Implications:

  • Silicone synovitis and giant cell formation are potential complications of silicone implants.
  • These findings underscore the importance of considering implant material in the differential diagnosis of bone lesions.
  • This case highlights a rare cause of bone destruction that can mimic malignancy.

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