Multiple myeloma with tadpolelike cells and rosette formation.

Area of Science:

• Hematology
• Oncology
• Pathology

Background:

• Multiple myeloma is a malignant proliferation of plasma cells.
• Bone marrow examination is crucial for diagnosing and characterizing plasma cell neoplasms.

Observation:

• A 65-year-old male presented with lower back pain.
• Bone marrow aspirate smears revealed unusual morphologic features.

Findings:

• The patient was diagnosed with multiple myeloma.
• Unique findings included tadpole-like plasma cells and cellular rosettes.
• These features mimicked neuroblastoma, highlighting a rare presentation.

Implications:

• This case expands the known morphologic spectrum of neoplastic plasma cells in multiple myeloma.
• Awareness of these atypical features is important for accurate diagnosis.
• Differential diagnosis should consider neuroblastoma in specific contexts.