Related Experiment Video
Updated: Aug 17, 2026

An In Ovo Model for Testing Insulin-mimetic Compounds
Published on: April 23, 2018
Antihyperglycemic activity of the aqueous extract of Urtica dioica
Mohamed Bnouham1, Fatima-Zahra Merhfour, Abderrahim Ziyyat
1Laboratoire de Physiologie et Pharmacologie Cellulaire, UFR de Physiologie et Pharmacologie, Département de Biologie, Faculté des Sciences, Université Mohamed Ier, Oujda B.P. 524, Morocco. bnouham@sciences.univ-oujda.ac.ma
Abstract:
When administered 30 min before glucose loading, the aqueous extract of Urtica dioica (nettle) (250 mg/kg) showed a strong glucose lowering effect. The decrease of glycemia has reached to 33+/-3.4% of the control value 1 h after glucose loading. This effect was persistent during 3 h. In contrast, nettle did not show hypoglycemic effect in alloxan-induced diabetic rats. The amount of glucose absorbed in a segment jejunum in situ was 8.05+/-0.68 mg in presence of nettle extract vs. 11.11+/-0.75 mg in control rats during 2 h (P<0.05). The results indicate that nettle has a significant antihyperglycemic effect in OGTT model. This effect may be caused in part by the reduction of intestinal glucose absorption. LD(50) is 3.5 g/kg (i.p.).
More Related Videos
08:15Antagonistic Effect of Jiawei Shengjiang San on a Rat Model of Diabetic Nephropathy: Related to EGFR/MAPK3/1 Signaling Pathway
Published on: May 10, 2024
08:44Elucidation of the Material Basis of Yiqi Qingjie Formula Against IgA Nephropathy Using UHPLC-Q-Orbitrap HRMS Integrated with Network Pharmacology
Published on: May 19, 2026
Related Concept Videos
Antihypertensive Drugs: Action of Diuretics
Oral Hypoglycemic Agents: Sulfonylureas
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Dipeptidyl Peptidase 4 Inhibitors