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Updated: Aug 30, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Cynthichlorine: a bioactive alkaloid from the tunicate Cynthia savignyi
A Abourriche1, Y Abboud, S Maoufoud
1Laboratoire de Chimie Organique Biomoléculaire Associé au C.N.R, Faculté des Sciences Ben M'Sik, BP 7955 Casablanca, Maroc. a.abourriche@univh2m.ac.ma
Abstract:
From ether extracts of the tunicate Cynthia savignyi, collected in Morocco, a new alkaloid-cynthichlorine-has been isolated. The structure of cynthichlorine has been characterized by extensive 2D-NMR data. Cynthichlorine possesses antifungal activity against two tomato pathogenic fungi: Botrytis cinerea and Verticillium albo atrum and antibacterial activity against Agrobacterium radiobacter, Escherichia coli and Pseudomonas aeruginosa and cytotoxicity against Artemia salina larvae.
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