Bioevaluation of radioactive bandages in a murine model of melanoma
Related Experiment Video
Updated: Aug 30, 2026
Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
Published on: June 7, 2019
A Mukherjee1, U Pandey, H D Sarma
1Radiopharmaceuticals Division, Animal Sciences, Cancer Research Institute, Mumbai, India.
Purpose:
To study the effectiveness of a radioactive bandage incorporating a beta(-) emitter for the treatment of superficial tumours like melanoma.
Materials And Methods:
(188)Re tin particles were immobilized on a bandage patch ((188)Re bandage). The effectiveness of the (188)Re bandage for controlling tumour growth was tested in C57BL/6 mice bearing BL6/FIO melanoma. The effect of the single dose delivered, two-dose treatment and time of contact of bandages on the skin was studied by following tumour size.
Results:
Tumour growth was delayed significantly in treated animals compared with controls. Complete tumour regression was observed with some doses of radiation. Histology studies and dose-rate calculations were also carried out to evaluate the effectiveness of (188)Re bandages.
Conclusions:
Radioactive bandages could be a promising modality for the treatment of skin cancers.