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Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
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Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
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Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
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Related Experiment Video

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Analyzing Tumor Gene Expression Factors with the CorExplorer Web Portal
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TSGDB: a database system for tumor suppressor genes.

Yanming Yang1, Li M Fu

  • 1University of Florida, Gainesville, FL, USA.

Bioinformatics (Oxford, England)
|November 25, 2003
PubMed
Summary
This summary is machine-generated.

A new web-based database system has been developed to catalog 174 tumor suppressor genes (TSGs). This resource provides comprehensive information and a user-friendly interface for accessing critical gene data.

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Area of Science:

  • Bioinformatics
  • Genomics
  • Molecular Biology

Background:

  • Tumor suppressor genes (TSGs) play a critical role in preventing cancer development.
  • A centralized, accessible resource for TSG information is essential for cancer research.
  • Existing databases may lack comprehensive or user-friendly access to TSG data.

Purpose of the Study:

  • To develop and implement a web-based database system for tumor suppressor genes.
  • To provide a centralized repository for detailed information on 174 identified tumor suppressor genes.
  • To create a user-friendly interface for querying and accessing gene-specific data.

Main Methods:

  • Construction and implementation of a web-based database system.
  • Inclusion of 174 tumor suppressor genes with individual web pages.
  • Development of a pull-down window for gene selection and a user-friendly query interface.
  • Dynamic generation of HTML web pages for query results.

Main Results:

  • A comprehensive database of 174 tumor suppressor genes is now available online.
  • Each gene entry includes detailed information such as gene name, aliases, organism, location, expression, structure, function, and references.
  • The database supports user-friendly queries, returning results in an accessible HTML format.

Conclusions:

  • The developed database provides a valuable and accessible resource for researchers studying tumor suppressor genes.
  • Facilitates easier access to comprehensive TSG information, potentially accelerating cancer research.
  • The user-friendly interface enhances data retrieval and utilization for scientific inquiry.