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In vitro Reconstitution of the Active T. castaneum Telomerase
09:25

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Published on: July 14, 2011

Template boundary definition in mammalian telomerase

Jiunn-Liang Chen1, Carol W Greider

  • 1Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Genes & Development
|November 25, 2003
PubMed
Summary

Helix P1b in human telomerase RNA is crucial for defining the template boundary during telomere repeat synthesis. Its disruption causes copying beyond the normal boundary, highlighting its essential role.

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