Related Experiment Video

Updated: Jul 6, 2026

Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection
11:32

Analysis of mRNA Nuclear Export Kinetics in Mammalian Cells by Microinjection

Published on: December 4, 2010

Nuclear export of microRNA precursors

Elsebet Lund1, Stephan Güttinger, Angelo Calado

  • 1Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, WI 53706, USA.

Science (New York, N.Y.)
|November 25, 2003
PubMed

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Before mRNAs are exported to the cytoplasm, it is crucial to check each mRNA for structural and functional integrity. Eukaryotic cells use several different mechanisms, collectively known as mRNA surveillance, to look for irregularities in mRNAs. Irregular or aberrant mRNA are rapidly degraded by various enzymes. If a defective mRNA escapes the surveillance, it would be translated into a protein which would either be non-functional or not function properly. One of the primary irregularities in...
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