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Published on: September 27, 2024
[Paroxysmal nocturnal hemoglobinuria associated with intestinal ischemia leading to small bowel perforation]
Vincent Quentin1, Michel Dinasquet, Nathalie Rioux-Leclercq
1Service des Maladies de l'Appareil Digestif, CHU Pontchaillou, 35033 Rennes.
Abstract:
Paroxysmal nocturnal hemoglobinuria is rarely associated with intestinal complications. We report a case of paroxysmal nocturnal hemoglobinuria with small bowel ischemia leading to ileal perforation. In the literature, an ulcerative jejuno-ileitis has been reported in 6 cases of intestinal ischemia, due to thrombosis of mucosal small vessels. This disease is usually revealed by abdominal pain. Based on published cases and our observation of intestinal ischemia leading to small bowel perforation, surgery should be considered as the first-line treatment, especially when small bowel lesions are limited.
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