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Fungal infections of the cornea

P A Thomas1

  • 1Department of Microbiology, Institute of Ophthalmology, Joseph Eye Hospital, Tiruchirapalli, India. philipthomas@satyam.net.in

Eye (London, England)
|November 25, 2003
PubMed
Abstract

Insights

Fungal keratitis is a significant eye problem for outdoor workers in tropical regions, often caused by trauma. Early diagnosis and appropriate antifungal treatment are crucial for managing this serious ocular condition.

Area of Science:

  • Ophthalmology
  • Mycology
  • Infectious Diseases

Background:

  • Fungal keratitis is a major cause of eye disease, particularly affecting outdoor workers in tropical and subtropical areas.
  • Trauma is the primary risk factor, with other contributing factors including ocular/systemic conditions and corticosteroid use.

Purpose of the Study:

  • To outline the key features of fungal corneal infections.
  • To discuss diagnostic methods and therapeutic strategies for fungal keratitis.

Main Methods:

  • Review of existing literature and personal clinical observations.
  • Diagnostic approaches include fungal cultures and direct microscopic examination of corneal samples.
  • Therapeutic options involve various topical and systemic antifungal agents.

Main Results:

  • Common causative agents include Fusarium, Aspergillus, Curvularia, and Candida species.
  • Topical natamycin (5%) is preferred for filamentous fungal infections, while topical amphotericin B (0.1-0.3%) is recommended for Candida infections.
  • Treatment success may require surgical intervention if medical therapy fails.

Conclusions:

  • Fungal keratitis remains a significant cause of vision loss, especially in agricultural communities in developing nations.
  • Understanding the interplay of fungal agents and host factors is vital for improving patient outcomes.

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