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Updated: Aug 30, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Molecular genetics of schizophrenia: a critical review
Neeraj Berry1, Vaidehi Jobanputra, Hemraj Pal
1Department of Psychiatry, All India Institute of Medical Sciences, New Delhi, India. berry_neeraj@hotmail.com
Abstract:
We present an overview of current progress and future directions in the molecular genetics of schizophrenia. We review linkage studies, involving the genome-wide scan of chromosomes with closely spaced polymorphic markers, and association studies of candidate genes, identified on the basis of receptors, neurotransmitters and response to certain drugs. The limitations of the research methodology involved in analyzing such a complex disorder are discussed, as are methods to strengthen this methodology with newer statistical and technological advances to give results that are replicable, statistically significant and applicable to a wider population. A greater understanding of the genetic mechanisms and the application of pharmacogenetics would lead to improvements in therapeutic interventions.
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