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Updated: Aug 30, 2026

Endothelialized Microfluidics for Studying Microvascular Interactions in Hematologic Diseases
Published on: June 22, 2012
Tumor microenvironment and hemorheological abnormalities
Gianfranco Baronzio1, Isabel Freitas, Hau C Kwaan
1Family Medicine Area, ASl 1 Legnano, Milano, Italy. freitas@unipv.it
Abstract:
This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.
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