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Related Experiment Videos

[Intrathecal morphine for postoperative pain].

H Schaer1, K Baasch, K Prochacka

  • 1Anaesthesie-Abteilung, Kreisspital Männedorf.

Der Anaesthesist
|November 1, 1992
PubMed
Summary
This summary is machine-generated.

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Low-dose intrathecal morphine (0.06-0.08 mg) effectively provided postoperative pain relief for over 20 hours in orthopedic and herniorrhaphy patients. This safe and simple technique significantly reduced the need for additional analgesics with minimal side effects.

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Intrathecal morphine use for postoperative pain was initially associated with high doses and frequent respiratory depression.
  • Previous studies identified that reducing morphine doses by tenfold improved safety and efficacy.
  • Doses below 0.1 mg of intrathecal morphine have not been linked to respiratory depression.

Purpose of the Study:

  • To evaluate the efficacy and safety of low-dose intrathecal morphine (0.06-0.08 mg) when mixed with local anesthetics for spinal anesthesia.
  • To assess the duration of analgesia and patient-reported side effects in surgical patients.

Main Methods:

  • A prospective study involving 30 patients (ASA grade I or II) undergoing orthopedic operations or herniorrhaphies.
  • Patients received spinal anesthesia with or without 0.06-0.08 mg of intrathecal morphine.

Related Experiment Videos

  • Analgesic effect was measured by the time to first analgesic demand; mood and side effects were also assessed.

    • Main Results:

    • Patients receiving intrathecal morphine required analgesia significantly later (median 1170 min) compared to the control group (median 275 min).
    • Half of the morphine group experienced analgesia lasting over 20 hours.
    • No significant differences in mood, nausea, or urinary retention were observed; pruritus was mild and infrequent.

    Conclusions:

    • A low dose of intrathecal morphine (0.06-0.08 mg) mixed with local anesthetic provides effective and prolonged postoperative analgesia.
    • This method is safe, simple, reliable, and virtually free of significant side effects when systemic opioids are avoided.
    • Non-opioid analgesics are recommended if pain relief is insufficient.