Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Intrathecal morphine for postoperative pain].

H Schaer1, K Baasch, K Prochacka

  • 1Anaesthesie-Abteilung, Kreisspital Männedorf.

Der Anaesthesist
|November 1, 1992
PubMed
Summary

Low-dose intrathecal morphine (0.06-0.08 mg) effectively provided postoperative pain relief for over 20 hours in orthopedic and herniorrhaphy patients. This safe and simple technique significantly reduced the need for additional analgesics with minimal side effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute and post-dosing effects of single-dose psilocybin for obsessive-compulsive disorder in a randomized, double-blind, placebo-controlled trial: an interpretative phenomenological analysis.

Frontiers in psychiatry·2025
Same author

Prerequisites for pastoral care and for the doctor.

Schweizerische Zeitschrift fur Psychologie und ihre Andwendungen. Revue suisse de psychologie, pure et appliquee·2010
Same author

[Sedation from spinal anesthesia].

Der Anaesthesist·1998
Same author

[The significance of preoperative autologous blood donation in general surgery].

Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1990
Same author

[Recovery, amnesia and affective state following propofol in comparison with thiopental].

Der Anaesthesist·1990
Same author

[Antagonism of flunitrazepam and fentanyl by flumazenil, naloxone or nalbuphine].

Der Anaesthesist·1990

Area of Science:

  • Anesthesiology
  • Pharmacology
  • Pain Management

Background:

  • Intrathecal morphine use for postoperative pain was initially associated with high doses and frequent respiratory depression.
  • Previous studies identified that reducing morphine doses by tenfold improved safety and efficacy.
  • Doses below 0.1 mg of intrathecal morphine have not been linked to respiratory depression.

Purpose of the Study:

  • To evaluate the efficacy and safety of low-dose intrathecal morphine (0.06-0.08 mg) when mixed with local anesthetics for spinal anesthesia.
  • To assess the duration of analgesia and patient-reported side effects in surgical patients.

Main Methods:

  • A prospective study involving 30 patients (ASA grade I or II) undergoing orthopedic operations or herniorrhaphies.
  • Patients received spinal anesthesia with or without 0.06-0.08 mg of intrathecal morphine.
  • Analgesic effect was measured by the time to first analgesic demand; mood and side effects were also assessed.

Main Results:

  • Patients receiving intrathecal morphine required analgesia significantly later (median 1170 min) compared to the control group (median 275 min).
  • Half of the morphine group experienced analgesia lasting over 20 hours.
  • No significant differences in mood, nausea, or urinary retention were observed; pruritus was mild and infrequent.

Conclusions:

  • A low dose of intrathecal morphine (0.06-0.08 mg) mixed with local anesthetic provides effective and prolonged postoperative analgesia.
  • This method is safe, simple, reliable, and virtually free of significant side effects when systemic opioids are avoided.
  • Non-opioid analgesics are recommended if pain relief is insufficient.

Related Experiment Videos