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Related Experiment Videos

[Enoxaparin induced skin necrosis].

Y Scharf, R Hershkoviz

    Harefuah
    |November 25, 2003
    PubMed
    Summary

    Skin necrosis is a rare side effect of low molecular weight heparin. This case highlights enoxaparin-induced skin necrosis in a patient treated for atrial fibrillation and left ventricle thrombus.

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    Area of Science:

    • Cardiology
    • Pharmacology
    • Dermatology

    Background:

    • Skin necrosis is a known complication associated with anticoagulant therapies, including Coumarin congeners and standard intravenous heparin.
    • Adverse effects of low molecular weight heparin (LMWH) are less frequently reported, particularly skin necrosis.

    Observation:

    • A 77-year-old female patient developed skin necrosis.
    • The patient was undergoing treatment for Atrial Fibrillation and a left ventricle thrombus.

    Findings:

    • The observed skin necrosis was attributed to Enoxaparin, a type of LMWH.
    • This case represents a rare instance of enoxaparin-induced skin necrosis.

    Implications:

    • This case underscores the importance of vigilance for rare adverse drug reactions, even with commonly used medications like Enoxaparin.
    • Healthcare providers should consider LMWH-induced skin necrosis in the differential diagnosis for patients presenting with such symptoms.
    • Further investigation into the mechanisms and risk factors for LMWH-induced skin necrosis may be warranted.

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