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Related Experiment Videos

Factors that affect the horizontal transfer of transposable elements.

Joana C Silva1, Elgion L Loreto, Jonathan B Clark

  • 1The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA. jsilva@tigr.org

Current Issues in Molecular Biology
|November 25, 2003
PubMed
Summary

Horizontal transfer, or the movement of transposable elements across species, varies by element class. Class II elements, using DNA intermediates, show higher horizontal transfer rates due to self-regulation of copy number.

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Area of Science:

  • Genetics and Genomics
  • Molecular Biology
  • Evolutionary Biology

Background:

  • Transposable elements (TEs) are mobile genetic sequences within genomes.
  • Horizontal transfer (HT) allows TEs to spread between species, impacting genome evolution.
  • Understanding TE behavior across species boundaries is crucial for evolutionary studies.

Purpose of the Study:

  • To review the occurrence and detection methods of horizontal transfer in animal transposable elements.
  • To analyze factors influencing the frequency of horizontal transfer, focusing on transposition mechanisms.
  • To explain the differential incidence of HT among TE families.

Main Methods:

  • Review of existing literature on animal transposable elements and horizontal transfer.

Related Experiment Videos

  • Analysis of transposition mechanisms (Class I vs. Class II elements).
  • Examination of copy number control and self-regulatory mechanisms in TEs.

    • Main Results:

    • Horizontal transfer frequency differs significantly among TE families.
    • Class I and Class II elements exhibit distinct patterns of horizontal transfer.
    • TEs utilizing DNA intermediates (Class II) show a higher incidence of horizontal transfer.

    Conclusions:

    • The presence of DNA intermediates during transposition correlates with higher horizontal transfer rates.
    • Self-regulatory mechanisms limiting TE copy number favor horizontal transfer.
    • Differences between Class I and Class II elements explain the observed variations in horizontal transfer prevalence.