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Postnatal and postprandial changes in plasma concentrations of glicentin in term and preterm infants

R Tadokoro1, T Shimizu, A Hosaka

  • 1Department of Paediatrics, Juntendo University School of Medicine, Tokyo, Japan.

Acta Paediatrica (Oslo, Norway : 1992)
|November 25, 2003
PubMed

Insights

Glicentin levels are higher in young children and increase after birth and feeding in infants. This suggests glicentin is crucial for intestinal growth in early life, especially in normal and low birthweight infants.

Area of Science:

  • Endocrinology
  • Pediatric Gastroenterology
  • Neonatology

Background:

  • Glicentin, an enteroglucagon component, influences intestinal mucosal trophic action.
  • Understanding glicentin's role is key to infant gut development.

Purpose of the Study:

  • To examine basal plasma glicentin concentrations in developing children.
  • To investigate postnatal and postprandial changes in infant plasma glicentin levels.

Main Methods:

  • Measured fasting plasma glicentin in healthy children and term/preterm infants.
  • Collected samples before and 30 minutes post-feeding during the first 14 days of life.

Main Results:

  • Higher basal glicentin in children under 1 year vs. 1-15 years.
  • Significantly increased basal glicentin in normal birthweight (NBW) and low birthweight (LBW) infants at 5-6 and 14 days post-birth compared to 1-2 days.
  • Postprandial glicentin increased significantly in NBW and LBW infants by 5-6 days, but not until 14 days in very-low birthweight (VLBW) infants.
  • No significant differences in glicentin levels between breastfed and formula-fed infants.

Conclusions:

  • Glicentin likely plays a vital role in intestinal mucosal growth during infancy.
  • Further research is needed to clarify glicentin's function in very-low birthweight infants.
Abstract

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