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Published on: February 8, 2019

Recurrent amyloidoma of soft tissue with exuberant giant cell reaction

Sanjay Mukhopadhyay1, Timothy A Damron, Alfredo L Valente

  • 1Department of Pathology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA. mukhopas@upstate.edu

Archives of Pathology & Laboratory Medicine
|November 25, 2003
PubMed

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...