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Premature ejaculation associated with citalopram withdrawal.

David E Adson¹, Michael Kotlyar

¹Department of Psychiatry, School of Medicine, University of Minnesota, Minneapolis, MN, USA. adson001@umn.edu

The Annals of Pharmacotherapy

|November 25, 2003

Summary

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Premature ejaculation may occur after discontinuing selective serotonin-reuptake inhibitors (SSRIs). Healthcare providers should inquire about sexual side effects during SSRI treatment and discontinuation.

Area of Science:

Psychiatry
Pharmacology
Sexual Medicine

Background:

Selective serotonin-reuptake inhibitors (SSRIs) are commonly prescribed for depression.
SSRI treatment is known to delay ejaculation in many patients.
Discontinuation of SSRIs typically results in a return to baseline sexual function.

Observation:

A case study reported a 43-year-old man experiencing premature ejaculation after discontinuing citalopram.
Symptoms included heightened genital sensitivity and rapid orgasm (approx. 1 minute).
These sexual adverse effects emerged 4-5 days post-discontinuation and resolved upon restarting citalopram.

Findings:

This is the first reported case of new-onset premature ejaculation as a withdrawal symptom from SSRI discontinuation.

Related Experiment Videos

Recurrent attempts to stop citalopram led to symptom recurrence, even with slow tapering.

A causality assessment indicated a probable link between citalopram withdrawal and the observed sexual dysfunction.

Implications:

Premature ejaculation should be considered a potential adverse effect of SSRI withdrawal.
Clinicians must proactively ask patients about sexual side effects during SSRI initiation and cessation.
Early identification and management of these withdrawal symptoms are crucial for patient well-being.