Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Can true monocular keratoconus occur?

Anthony J Phillips1

  • 1Contact Lens Unit, Deprtment of Ophthalmology, Flinders Medical Centre, Flinders University, Bedford Park, South Australia, Australia.

Clinical & Experimental Optometry
|November 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraluminal oxygen mitigates acute mesenteric ischaemia: a systematic review of methods and outcomes in animal studies.

ANZ journal of surgery·2022
Same author

The Gut-Lymph Model Gives New Treatment Strategies for Organ Failure.

JAMA surgery·2022
Same author

Mesenteric lymph: the bridge to future management of critical illness.

JOP : Journal of the pancreas·2007
Same author

Stickler syndrome.

Clinical & experimental optometry·2002
Same author

Spontaneous tinting of rigid gas permeable contact lenses during wear.

Clinical & experimental optometry·2002
Same journal

An international survey of low vision rehabilitation services.

Clinical & experimental optometry·2026
Same journal

Readiness of the tabletop screen-based perimetry tests for screening and monitoring glaucoma.

Clinical & experimental optometry·2026
Same journal

Validation of the vision quality of life-time survey: comparison with the convergence insufficiency symptom survey.

Clinical & experimental optometry·2026
Same journal

Measuring contrast sensitivity in school children and young adults: a comparison between Pelli-Robson and SpotChecks charts.

Clinical & experimental optometry·2026
Same journal

Three-year retinal and visual outcomes after ultraviolet- and blue light-filtering intraocular lenses.

Clinical & experimental optometry·2026
Same journal

Repeatability of choroidal optical coherence tomography angiography metrics in healthy young adults.

Clinical & experimental optometry·2026
See all related articles

Keratoconus is often genetic, typically affecting both eyes. This case study presents a rare instance of true monocular keratoconus, highlighting extreme variable gene expression.

Area of Science:

  • Ophthalmology
  • Genetics

Background:

  • Keratoconus is increasingly recognized as a genetic disorder.
  • Variable gene expression often leads to differing severity in both eyes, resulting in pseudo-monocular cases.

Observation:

  • A rare case of true monocular keratoconus, present for over 23 years, is documented.
  • The unaffected eye showed normal corneal thickness and no signs of forme fruste keratoconus via videokeratoscopy.
  • No history of monocular eye rubbing was reported.

Findings:

  • The presented case demonstrates a unilateral manifestation of keratoconus, with advanced disease in one eye requiring corneal grafting.
  • Videokeratoscopy confirmed the absence of subclinical disease in the contralateral eye, ruling out forme fruste.
  • The subject's age suggests no future onset is likely.

Related Experiment Videos

Implications:

  • This case represents an extreme example of variable gene expression in inherited keratoconus.
  • It underscores the importance of considering true monocular presentations, however rare, in the genetic understanding of keratoconus.