Combined effects of noise and cisplatin: short- and long-term follow-up

The combined effects of noise exposure and intravenous cisplatin injection on electrophysiologic hearing thresholds in guinea pigs were studied with short-term and long-term follow-up. The combined effects on the permanent threshold shift were dependent on the order of exposure. A potentiation was achieved when noise exposure preceded cisplatin injection by 30 minutes or by 3 days. Cisplatin injection 2 or 3 days before noise exposure produced no significant potentiation or inhibition. The combined effects on the temporary threshold shift were not influenced by the sequence of exposure.