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[Antibiotic residues and digestive microflora].

D E Corpet1

  • 1Laboratoire des Xénobiotiques, INRA, Toulouse.

Annales De Gastroenterologie Et D'Hepatologie
|October 1, 1992
PubMed
Summary

Antibiotic residues in food do not significantly alter human gut flora or promote drug-resistant bacteria. Studies using animal models and human volunteers confirm minimal impact on gut microbiota composition and resistance.

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Area of Science:

  • Microbiology
  • Pharmacology
  • Gastroenterology

Background:

  • The human gut microbiome plays a crucial role in health and disease.
  • Concerns exist regarding the potential impact of antibiotic residues in food on gut flora and the selection of drug-resistant bacteria.

Purpose of the Study:

  • To investigate whether antibiotic residues in food can modify the human gut flora.
  • To determine if antibiotic residues select for drug-resistant bacteria in the gut.

Main Methods:

  • Human volunteers were administered ampicillin or oxytetracycline, and fecal excretion of resistant enterobacteria was monitored.
  • Germ-free mice colonized with human gut flora (heteroxenic) and mice with specific bacterial strains (dixenic) were used as models.
  • Minimum antibiotic selection doses were determined in animal models, comparing them to potential human dietary intake.

Main Results:

  • No significant changes in fecal excretion of resistant enterobacteria were observed in human volunteers.
  • Animal models showed that minimum antibiotic selection doses were lower than typical human dietary intake.
  • Fecal resistant enterobacteria levels decreased when volunteers consumed a sterile diet, indicating food as a source.

Conclusions:

  • Antibiotic residues in food do not appear to significantly modify the human gut flora.
  • The study suggests that antibiotic residues do not meaningfully contribute to the selection of drug-resistant bacteria in the gut microbiome.
  • Food is a direct source of fecal resistant enterobacteria, rather than modifications induced by antibiotic residues.

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