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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens
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Two Methods for Establishing Primary Human Endometrial Stromal Cells from Hysterectomy Specimens

Published on: May 23, 2014

beta 1C Integrin expression in human endometrial proliferative diseases

Mariarosaria Lovecchio1, Eugenio Maiorano, Rosa A Vacca

  • 1Institute of Biomembranes and Bioenergetics, National Research Council, Bari.

The American Journal of Pathology
|November 25, 2003
PubMed

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Integrins

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Activation of Integrins

Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
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Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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