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Simian virus 40 sequences in malignant lymphomas in Japan
Shin-ichi Nakatsuka1, Angen Liu, Zhiming Dong
1Department of Pathology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Cancer Research
|November 25, 2003
Summary
Simian virus 40 (SV40) DNA was detected in Japanese lymphoma cases, suggesting its potential role in cancer development. This finding indicates SV40 may be an emerging factor in malignant lymphoma globally.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- Recent US studies detected Simian virus 40 (SV40) in over 40% of non-Hodgkin's lymphoma (NHL) cases.
- SV40 contamination in poliovaccines (1955-1963) is a suspected source of SV40 in NHL.
Purpose of the Study:
- To investigate the presence and potential role of SV40 in malignant lymphoma in Japan.
- To compare SV40 detection rates in Japanese lymphoma patients with healthy controls.
Main Methods:
- Analysis of 122 non-Hodgkin's lymphoma (NHL) and 3 Hodgkin's lymphoma cases from Japan for SV40 sequences.
- Comparison of SV40 detection rates between patient groups and previously reported healthy volunteers.
Main Results:
- SV40 sequences were detected in 19% of diffuse large B-cell lymphoma cases, significantly higher than in healthy controls (4.7%).
- No significant difference in SV40 frequency was observed based on birth year (pre-1950, 1951-1963, post-1964).
Conclusions:
- SV40 is a potential etiological factor in diffuse large B-cell lymphoma in Japan.
- SV40 may be an emerging cause of malignant lymphoma in both the US and Japan.