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Related Experiment Videos

Hematopoietic progenitors express neural genes.

James Goolsby1, Marie C Marty, Dafna Heletz

  • 1Department of Neurology, University of Maryland School of Medicine, and Multiple Sclerosis Center of Excellence, Veterans Affairs Medical Center, Baltimore, MD 21201, USA.

Proceedings of the National Academy of Sciences of the United States of America
|November 25, 2003
PubMed
Summary

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Bone marrow cells express neural and oligodendroglial genes. Transplanted CD34+ bone marrow cells differentiate into neural or glial cells in the brain, suggesting potential pluripotency.

Area of Science:

  • Stem Cell Biology
  • Neuroscience
  • Hematology

Background:

  • Bone marrow cells can reportedly develop neural phenotypes.
  • Previous work indicated bone marrow cells express neural myelin basic protein gene products.

Purpose of the Study:

  • To investigate the neural and oligodendroglial gene expression in ex vivo bone marrow cells.
  • To determine the differentiation potential of CD34+ bone marrow cells in vivo.

Main Methods:

  • Analysis of gene expression (Pax-6, neurofilament H, NeuN, HuC/HuD, GAD65, CNPase) in ex vivo bone marrow cells.
  • Flow cytometry for CD34+ and hematopoietic progenitor markers (CD45, Sca-1, etc.).
  • Transplantation of CD34+ cells into adult mouse brain and analysis of cell markers.

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Main Results:

  • A subset of ex vivo bone marrow cells expressed neuronal and oligodendroglial genes but not astroglial GFAP.
  • Cultured CD34+ cells exhibited hematopoietic progenitor markers and expressed neuronal/oligodendroglial genes.
  • Transplanted CD34+ cells differentiated into distinct neuronal/oligodendroglial or astroglial populations in the brain.

Conclusions:

  • Bone marrow contains CD34+ cells expressing neuronal and oligodendroglial genes.
  • These cells can differentiate into neural and glial lineages within the brain.
  • The expression of early developmental transcription factors (Rex-1, Oct-4) suggests potential pluripotent embryonic-like stem cell properties.