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PARP cleavage as a means of assessing apoptosis

Peter Mullen1

  • 1Cancer Research UK Oncology Unit, Western General Hospital, Edinburgh, UK.

Methods in Molecular Medicine
|November 25, 2003
PubMed
Abstract

No abstract available in PubMed .

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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...

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