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Related Experiment Videos

Bioavailable testosterone with age and erectile dysfunction.

Akira Tsujimura1, Kiyomi Matsumiya, Yasuhiro Matsuoka

  • 1Department of Urology, Osaka University Graduate School of Medicine, Suita, Japan.

The Journal of Urology
|November 25, 2003
PubMed
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Bioavailable testosterone (BT) is a key indicator for diagnosing and treating partial androgen deficiency of the aging male (PADAM). Measuring BT is essential for aging men, as it correlates with erectile function and age.

Area of Science:

  • Endocrinology
  • Andrology
  • Gerontology

Background:

  • Partial androgen deficiency of the aging male (PADAM) presents with symptoms like sexual dysfunction and depression.
  • Bioavailable testosterone (BT) is the current gold standard for hypogonadism diagnosis.

Purpose of the Study:

  • To investigate the relationship between bioavailable testosterone (BT) and other hormones in aging males.
  • To clarify the association between BT and PADAM symptoms, including sexual dysfunction and depression, in relation to patient age.

Main Methods:

  • Study included 130 male patients attending sexual function clinics.
  • Assessed endocrinological profiles, sexual dysfunction, and depression using self-reported questionnaires.
  • Analyzed correlations between age, testosterone measures, hormonal profiles, and PADAM symptoms.

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Main Results:

  • Serum total testosterone levels did not decline with age, but sex hormone-binding globulin increased.
  • Bioavailable testosterone (BT) and free testosterone significantly decreased with age and correlated with total and free testosterone.
  • Improved erectile function scores (International Index of Erectile Function-5) correlated significantly with increased BT, but depression scores did not.

Conclusions:

  • Bioavailable testosterone (BT) is a valuable marker for diagnosing and managing PADAM in aging males.
  • BT shows significant correlation with age and erectile function, supporting its clinical utility.
  • Measuring serum testosterone, particularly BT, is crucial for evaluating aging men's health.