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Methylene 3, 4 dioxymethamphetamine-induced acute myocardial infarction

Ting-I Lai1, Juey-Jen Hwang, Cheng-Chung Fang

  • 1Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Republic of China.

Annals of Emergency Medicine
|November 25, 2003
PubMed

Insights

Methylene 3,4-dioxymethamphetamine (MDMA) use can cause rare but severe acute myocardial infarction. This case highlights the risk of coronary artery thrombosis following MDMA ingestion.

Area of Science:

  • Cardiology
  • Toxicology
  • Pharmacology

Background:

  • Methylene 3,4-dioxymethamphetamine (MDMA) is a popular recreational drug with known cardiovascular risks.
  • While arrhythmias and heart failure are common, MDMA-induced acute myocardial infarction (AMI) is rarely documented.

Observation:

  • A young man presented with acute myocardial infarction shortly after recreational MDMA use.
  • Emergency angiography revealed massive thrombosis in the right coronary artery.

Findings:

  • The patient was successfully treated with glycoprotein IIb/IIIa inhibitors and intracoronary urokinase.
  • Coronary angiography post-treatment showed a patent artery without significant stenosis, suggesting a thrombotic event rather than atherosclerosis.

Implications:

  • This case underscores the potential for MDMA to precipitate acute myocardial infarction through coronary thrombosis.
  • Clinicians should consider MDMA toxicity in young patients presenting with myocardial infarction, even without typical risk factors.
  • Further research into the mechanisms of MDMA-induced cardiovascular events is warranted.

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