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Survivin, versatile modulation of cell division and apoptosis in cancer

Dario C Altieri1

  • 1Department of Cancer Biology and the Cancer Center, LRB-428, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. dario.altieri@umassmed.edu

Oncogene
|November 25, 2003
PubMed

Insights

Survivin, a key protein in cell division and apoptosis, is highly expressed in tumors. This research explores its functions and potential as a target for novel cancer therapies.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Cancer Research

Background:

  • Survivin is a member of the inhibitor of apoptosis (IAP) gene family.
  • It plays a role in cell cycle regulation, mitosis, and apoptosis.
  • Survivin is notably expressed in tumors but not in normal tissues.

Purpose of the Study:

  • To review current evidence on survivin's functions in cell death and division.
  • To explore emerging concepts regarding survivin's multifaceted roles.
  • To outline strategies for targeting survivin in cancer therapy.

Main Methods:

  • Literature review of basic and translational research on survivin.
  • Analysis of survivin's involvement in apoptosis and cell division mechanisms.
  • Examination of survivin's potential in cancer diagnosis and treatment.

Main Results:

  • Survivin regulates mitosis and influences apoptosis, though its apoptotic inhibition may be selective.
  • Its distinct expression pattern in tumors makes it a significant cancer biomarker.
  • Survivin's pathways offer potential for developing new cancer therapeutic strategies.

Conclusions:

  • Survivin is a crucial protein with dual roles in cell division and apoptosis.
  • Its tumor-specific expression highlights its importance in cancer biology.
  • Targeting survivin presents a promising avenue for innovative cancer treatments.

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