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Correlation between diagnostic 59Fe2+-absorption and serum ferritin concentration in man
Zeitschrift Fur Naturforschung. Section C, Biosciences
|November 1, 1977
Summary
Diagnostic iron absorption is a sensitive indicator of depleted iron stores, decreasing before serum ferritin levels in iron deficiency. This inverse relationship highlights early detection markers for iron deficiency anemia.
Area of Science:
- Hematology
- Clinical Biochemistry
- Nutritional Science
Background:
- Iron deficiency is a global health concern.
- Serum ferritin is a common biomarker for iron status.
- Accurate and early diagnosis of iron deficiency is crucial.
Purpose of the Study:
- To investigate the relationship between diagnostic iron absorption and serum ferritin levels.
- To compare iron absorption as an indicator of iron deficiency with serum ferritin concentration.
- To determine the sensitivity and timing of these markers in detecting depleted iron stores.
Main Methods:
- Utilized a diagnostic test measuring 59Fe2+-absorption in humans.
- Measured serum ferritin concentrations.
- Correlated 59Fe2+-absorption with serum ferritin levels and bone marrow iron stores.
Main Results:
- A strong inverse correlation (r = -0.832, P < 0.0001) was found between 59Fe2+-absorption and serum ferritin.
- This correlation is comparable to that with bone marrow iron stores (r = -0.88).
- Increased 59Fe2+-absorption indicated depleted iron stores earlier than decreased serum ferritin.
Conclusions:
- Diagnostic 59Fe2+-absorption is a sensitive and early indicator of iron deficiency.
- Serum ferritin levels decrease later in the progression of iron deficiency.
- This study suggests 59Fe2+-absorption may be a valuable tool for early iron deficiency diagnosis.