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Related Experiment Videos

Platelet loss across the hemofilter during continuous hemofiltration.

J Mulder1, H K Tan, R Bellomo

  • 1Department of Intensive Care, Austin Hospital, Melbourne, Australia.

The International Journal of Artificial Organs
|November 26, 2003
PubMed
Summary

The hemofilter used in continuous renal replacement therapy (CRRT) may cause a small but significant drop in platelet counts. Higher blood flow rates during CRRT appear to reduce this platelet loss.

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Hematology

Background:

  • Thrombocytopenia is frequent in intensive care unit (ICU) patients undergoing continuous renal replacement therapy (CRRT).
  • The direct contribution of hemofilters to platelet loss in CRRT remains unclear.

Purpose of the Study:

  • To quantify the direct impact of hemofilters on platelet counts during CRRT.
  • To investigate the relationship between blood flow and platelet loss across hemofilters.

Main Methods:

  • Prospective, observational study in an ICU of a university hospital.
  • Simultaneous pre-filter and post-filter blood samples were analyzed for platelet counts.
  • A correction factor adjusted for hemoconcentration due to ultrafiltration.

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Main Results:

  • A statistically significant mean platelet count decrease of 2.32 x 10(9)/L across the hemofilter was observed.
  • Higher blood flow rates correlated with reduced platelet loss (p=0.015).
  • No significant red blood cell count decrease was noted, though machine-specific effects on red cell loss were found.

Conclusions:

  • Hemofilters may contribute to thrombocytopenia in CRRT patients through platelet destruction or retention.
  • Increased blood flow during CRRT may mitigate hemofilter-induced platelet loss.
  • Findings aid in evaluating low platelet counts in CRRT patients.