T cell immunity to brucellosis

Brucellosis is an ancient disease of animals and man that still threatens the health and prosperity of many, primarily in the third world, who depend on animal agriculture for their livelihood. Further, its pathogenicity and the facts that it is zoonotic is effectively eradicated from many Western nations make it a dangerous bioterrorism threat. Targeted human vaccination may reduce the various threats brucellosis poses. Significant effort has been expended toward this goal and many candidate vaccines exist. However, the ideal vaccine would be a subunit vaccine that specifically targets only the critical aspects of the immune response necessary to induce immunity. Much about the immune response, in particular the T cell response, remains to be discovered in order to accomplish that goal. In this review we focus on T cell responses to brucellosis with particular attention to the specific roles of T cell subtypes. We also point out areas of research on T cell responses that may allow exploitation of cutting edge vaccine technologies for the next generation vaccine for brucellosis.