Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leaky neural integration observed in square-wave jerks.

Yasuo Suzuki1, Manabu Kase, Masato Hashimoto

  • 1Department of Ophthalmology, Sapporo Medical University, School of Medicine, Sapporo, Japan.

Japanese Journal of Ophthalmology
|November 26, 2003
PubMed
Summary

Square-wave jerks (SWJs) and visually guided saccades share identical velocity-to-position integrator outputs. This suggests SWJs originate from neural circuits involving a pulse generator and integrator.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of age, sex, and axial length on macular structure and perfusion in normal eyes.

Medicine·2026
Same author

Lacrimal gland pleomorphic adenoma: two referral center analyses in Hokkaido, Japan.

International journal of ophthalmology·2025
Same author

Superior Oblique Myokymia Caused by Vascular Compression in the Peripheral Trochlear Nerve: A Case Report.

Neurosurgery practice·2025
Same author

Intravenous immunoglobulin for the acute treatment of refractory optic neuritis in Japan.

Japanese journal of ophthalmology·2025
Same author

Sex Differences in Age-Related Changes in Retinal Arteriovenous Area Based on Deep Learning Segmentation Model.

Ophthalmology science·2025
Same author

Retrobulbar Optic Nerve Diastasis Caused by Intraoptic Nerve Cyst.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society·2025

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Neurophysiology

Background:

  • Square-wave jerks (SWJs) are abnormal eye movements characterized by rapid, jerky shifts.
  • Understanding the underlying neuronal mechanisms of SWJs is crucial for diagnosing and managing related neurological conditions.

Observation:

  • A patient presented with horizontal nystagmus and SWJs during fixation.
  • Eye movements were recorded using search coil methods and quantitatively analyzed.
  • Analysis revealed exponential drifts following visually guided saccades and SWJs, indicative of a leaky velocity-to-position integrator.

Findings:

  • SWJs and visually guided saccades share identical velocity-to-position integrator outputs.
  • The characteristics of drifts following SWJs were similar to those after saccades.

Related Experiment Videos

  • SWJs are generated by neural circuits comprising a pulse generator and a velocity-to-position integrator.

    • Implications:

    • This study clarifies the neuronal basis of SWJs, linking them to the velocity-to-position integrator.
    • Findings suggest a common neural substrate for SWJs and normal saccadic eye movements.
    • Further research can explore therapeutic targets within these identified neural circuits.