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Locked-in syndrome.

J Sepcić1, D Sepić-Grahovac, J Strenja-Grubesić

  • 1Department of Neurology, Medical Faculty, University of Rijeka, Croatia.

Neurologia Croatica : Glasilo Udruzenja Neurologa Jugoslavije = Official Journal of Yugoslav Neurological Association
|January 1, 1992
PubMed
Summary
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This case report details a young fisherman with locked-in syndrome due to basilar artery thrombosis. Autopsy confirmed pontine infarction, highlighting the critical role of the basilar artery in brainstem function.

Area of Science:

  • Neurology
  • Neuroscience
  • Clinical Medicine

Background:

  • Locked-in syndrome is a rare neurological condition characterized by preserved consciousness but complete paralysis.
  • Basilar artery thrombosis is a critical cause of brainstem stroke, often leading to severe neurological deficits.

Observation:

  • A young fisherman presented with locked-in syndrome, exhibiting intact consciousness, spastic quadriplegia, voluntary eye blinking, and anarthria.
  • Clinical examination revealed thrombosis of the basilar artery and altered cerebral cortical bioelectrogenesis.

Findings:

  • Autopsy confirmed thrombosis of the basilar artery and ventrobasal pontine infarction.
  • The patient survived for 41 days, with the clinical presentation consistent with the pathological findings.

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Implications:

  • This case underscores the devastating impact of basilar artery thrombosis on brainstem structures.
  • Understanding the clinical manifestations and pathological correlates of locked-in syndrome is crucial for differential diagnosis and patient management.