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Related Experiment Videos

Circulating ghrelin levels in celiac patients.

Maddalena Peracchi1, Dario Conte, Claudia Terrani

  • 1Gastroenterology, IRCCS-Ospedale Maggiore, University of Milan, Milan, Italy.

The American Journal of Gastroenterology
|November 26, 2003
PubMed
Summary

Ghrelin levels are elevated in active celiac disease (CD) and correlate with intestinal damage. Treatment with a gluten-free diet normalizes ghrelin levels, suggesting a link between gut inflammation and this hormone.

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Area of Science:

  • Endocrinology
  • Gastroenterology
  • Metabolic Research

Background:

  • Ghrelin, a gut-brain peptide, regulates energy homeostasis and food intake.
  • Its role in malabsorption syndromes like celiac disease (CD) is not well understood.

Purpose of the Study:

  • To investigate circulating ghrelin levels in adults with untreated and treated celiac disease.
  • To compare ghrelin levels with healthy controls and assess correlations with disease severity.

Main Methods:

  • Fasting serum ghrelin levels were measured in 30 untreated CD patients, 13 treated CD patients, and 30 healthy controls.
  • Correlations with intestinal mucosal lesion severity and body mass index were analyzed.

Main Results:

Related Experiment Videos

  • Active CD patients exhibited significantly higher ghrelin levels compared to controls.
  • Ghrelin levels positively correlated with the severity of intestinal mucosal lesions in untreated CD.
  • Gluten-free diet treatment normalized ghrelin levels and introduced a negative correlation with body mass index.

    • Conclusions:

    • Elevated ghrelin levels are characteristic of active celiac disease and are linked to intestinal inflammation.
    • This study provides the first evidence of a relationship between ghrelin and inflammatory processes in CD.
    • Hormonal, metabolic, and nutritional factors likely influence ghrelin secretion in this condition.