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Engineering Antiviral Agents via Surface Plasmon Resonance
Published on: June 14, 2022
Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans
Fátima Lasala1, Eva Arce, Joaquín R Otero
1Laboratorio de Microbiología Molecular, Servicio de Microbiología, Hospital Universitario 12 de Octubre, Madrid, Spain.
Antimicrobial Agents and Chemotherapy
|November 26, 2003
Abstract:
We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.
